Architecture of inherited susceptibility to common cancer

被引：165

作者：

Fletcher, Olivia ^{[2
]}

Houlston, Richard S. ^{[1
]}

机构：

[1] Inst Canc Res, Sect Canc Genet, Sutton SM2 5NG, Surrey, England

[2] Inst Canc Res, Breakthrough Breast Canc Res Ctr, London SW3 6JB, England

来源：

NATURE REVIEWS CANCER | 2010年 / 10卷 / 05期

关键词：

GENOME-WIDE ASSOCIATION; FAMILIAL COLORECTAL-CANCER; BREAST-CANCER; LUNG-CANCER; PROSTATE-CANCER; CONFERS SUSCEPTIBILITY; ADENOMATOUS POLYPOSIS; IDENTIFIES VARIANTS; GENETIC-VARIATION; RISK;

D O I：

10.1038/nrc2840

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

This Timeline article looks back at 40 years of research into the inherited genetic basis of cancer and the insights these studies have yielded. Early epidemiological research provided evidence for the 'two-hit' model of cancer predisposition. During the 1980s and 1990s linkage and positional cloning analyses led to the identification of high-penetrance cancer susceptibility genes. The past decade has seen a shift from models of predisposition based on single-gene causative mutations to multigenic models. These models suggest that a high proportion of cancers may arise in a genetically susceptible minority as a consequence of the combined effects of common low-penetrance alleles and rare disease-causing variants that confer moderate cancer risks.

引用

页码：353 / 361

页数：9

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