The use of solid physical models for the study of macromolecular assembly

被引:13
作者
Bailey, MJ
Schulten, K
Johnson, JE
机构
[1] Scripps Res Inst, Dept Biol Mol, La Jolla, CA 92037 USA
[2] Univ Calif San Diego, San Diego Supercomp Ctr, La Jolla, CA 92037 USA
[3] Univ Calif San Diego, Dept Appl Mech & Engn Sci, La Jolla, CA 92037 USA
[4] Univ Illinois, Beckman Inst, Urbana, IL 61801 USA
关键词
D O I
10.1016/S0959-440X(98)80039-0
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The use of modern technology in the construction of accurate solid macromolecular models based on atomic coordinates and electron density functions has led us to re-examine the usefulness of physical models as tools for understanding molecular assembly and for designing detailed experimental and computational studies of the assembly process. Recent developments include the construction of new models, which have provided insights into the assembly of viruses and light harvesting complexes.
引用
收藏
页码:202 / 208
页数:7
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