An IL-13 promoter polymorphism associated with increased risk of allergic asthma

被引：215

作者：

Kraan, TCTMV

van Veen, A

Boeije, LCM

van Tuyl, SAP

de Groot, ER

Stapel, SO

Bakker, A

Verweij, CL

Aarden, LA

van der Zee, JS

机构：

[1] Univ Amsterdam, Dept Autoimmune Dis, CLB, NL-1066 CX Amsterdam, Netherlands

[2] Univ Amsterdam, Expt & Clin Immunol Lab, NL-1066 CX Amsterdam, Netherlands

[3] Acad Med Ctr, Dept Pulmonol, Amsterdam, Netherlands

[4] Univ Amsterdam, Dept Allergy, CLB, NL-1066 CX Amsterdam, Netherlands

[5] Acad Hosp, Dept Rheumatol, Leiden, Netherlands

来源：

GENES AND IMMUNITY | 1999年 / 1卷 / 01期

关键词：

human; cytokines; allergy and immunology; genetics; Th2; cells;

D O I：

10.1038/sj.gene.6363630

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

IL-13 plays a crucial role in the development of allergic asthma by several mechanisms, including induction of IgE antibodies, airway eosinophilia and hyper-reactivity. We previously established a deregulated production of IL-13 by T cells from allergic asthma patients. In this report we describe the identification of a novel IL-13 promoter polymorphism (C to T exchange) at position - 1055. The IL-13 - 1055 TT genotype is associated with allergic asthma (P = 0.002), altered regulation of IL-13 production (P < 0.002), and increased binding of nuclear proteins to this region. We postulate that the presence of this polymorphism predisposes to the development of allergic asthma.

引用

页码：61 / 65

页数：5

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