Apolipoprotein E and cognitive performance:: A meta-analysis

被引：351

作者：

Small, BJ

Rosnick, CB

Fratiglioni, L

Bäckman, L

机构：

[1] Univ S Florida, Sch Aging Studies, Tampa, FL 33620 USA

[2] Karolinska Inst, Div Geriatr Epidemiol, Aging Res Ctr, Stockholm, Sweden

来源：

PSYCHOLOGY AND AGING | 2004年 / 19卷 / 04期

关键词：

D O I：

10.1037/0882-7974.19.4.592

中图分类号：

R4 [临床医学]; R592 [老年病学];

学科分类号：

1002 ; 100203 ; 100602 ;

摘要：

The epsilon4 allele of the apolipoprotein E (APOE) gene is a known risk factor for Alzheimer's disease and may also affect cognitive performance in normal aging. Evidence of the presence and magnitude of epsilon4-related cognitive deficits was examined with a meta-analysis of the available literature. Thirty-eight studies were included, and cognitive performance was collapsed into 8 domains. Results indicated significant APOE-epsilon4 group differences for global cognitive functioning, episodic memory, and executive functioning, in favor of non-epsilon4 carriers. In addition, older age and APOE-epsilon4 heterozygosity was associated with smaller epsilon4-related impairments. The meta-analysis results suggest that APOE-epsilon4 genotype does affect cognitive performance in healthy aging, although the influence is relatively small and specific to certain domains of cognitive performance.

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页码：592 / 600

页数：9

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