Risperidone in idiopathic and symptomatic dystonia: preliminary experience

被引：8

作者：

Grassi, E ^{[1
]}

Latorraca, S ^{[1
]}

Piacentini, S ^{[1
]}

Marini, P ^{[1
]}

Sorbi, S ^{[1
]}

机构：

[1] Univ Florence, Dept Neurol & Psychiat Sci, I-50134 Florence, Italy

来源：

NEUROLOGICAL SCIENCES | 2000年 / 21卷 / 02期

关键词：

idiopathic dystonia; symptomatic dystonia; movement disorders; risperidone; pharmacological therapy; neuropsychiatric disorders;

D O I：

10.1007/s100720070108

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Risperidone is a heterocyclic neuroleptic with prominent antiserotoninergic (5HT(2)) as well as antidopaminergic (D-2) activity. We studied the efficacy of risperidone in the treatment of idiopathic and symptomatic dystonias in seven patients using the Fahn and Marsden rating scale for torsion dystonia before and after four weeks of treatment (2-6 mg/day). The twisting and involuntary movements with abnormal postures decreased in all the patients treated, with a statistically significant mean improvement (41%; p = 0.009, CI 95%). Our results suggest that risperidone is useful in idiopathic and symptomatic dystonia.

引用

页码：121 / 123

页数：3

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