Three-dimensional photoacoustic imaging of blood vessels in tissue

被引：415

作者：

Hoelen, CGA ^{[1
]}

de Mul, FFM ^{[1
]}

Pongers, R ^{[1
]}

Dekker, A ^{[1
]}

机构：

[1] Univ Twente, Dept Appl Phys, NL-7500 AE Enschede, Netherlands

来源：

OPTICS LETTERS | 1998年 / 23卷 / 08期

关键词：

D O I：

10.1364/OL.23.000648

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We applied photoacoustics as a tissue tomography technique for the detection of blood concentrations, e.g., angiogenesis around tumors. We imaged blood vessels in highly scattering samples, using 532-nm light, to depths of similar to 1 cm. The samples were real tissue (chicken breast) or 10% dilutions of Intralipid-10%. The blood flowed through nylon capillaries. Polyvinylidene difluoride (PVdF) piezoelectric detectors were used in a surface-scanning mode. We demonstrate the sensitivity of the technique by photoacoustic detection of single red blood cells upon a glass plate. Lateral resolution is limited by the detector diameter (200 mu m). The depth resolution is similar to 10 mu m. (C) 1998 Optical Society of America.

引用

页码：648 / 650

页数：3

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