Antimycobacterial crude plant extracts from South, Central, and North America

被引：51

作者：

Cantrell, CL

Fischer, NH

Urbatsch, L

McGuire, MS

Franzblau, SG ^{[1
]}

机构：

[1] Louisiana State Univ, Dept Chem, Baton Rouge, LA 70803 USA

[2] Louisiana State Univ, Dept Biol Sci, Baton Rouge, LA 70803 USA

[3] GWL Hansens Dis Ctr, Baton Rouge, LA USA

来源：

PHYTOMEDICINE | 1998年 / 5卷 / 02期

基金：

美国国家卫生研究院;

关键词：

antitubercular; antimycobacterial; BACTEC-radiorespirometric assay; extracts; plants; Mycobacterium tuberculosis; Mycobacterium avium; mycobacteria; tuberculosis;

D O I：

10.1016/S0944-7113(98)80011-1

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two-hundred and thirty crude organic extracts from 118 plant species distributed among 10 families were evaluated for anti-mycobacterial activity. Activity was determined against Mycobacterium tuberculosis H37RV and Mycobacterium avium using the BACTEC 460 radiorespirometric assay. At 100 mu g/ml, twenty-four and ten of the extracts caused more than 95% inhibition of growth of M. tuberculosis and M. avium, respectively. The most active plant species (100% inhibition) were Borrichia frutescens, Solidago arguta, and Inula helenium against M. tuberculosis, Euthamia leptocephala against M. avium, and Erigeron strigosus and Magnolia acuminata against both mycobacteria.

引用

页码：137 / 145

页数：9

共 18 条

[1]

BICHKANOVA SA, 1977, RASTIT RESUR, V13, P428

[2] Antimycobacterial cycloartanes from Borrichia frutescens [J].

Cantrell, CL ;

Lu, TS ;

Fronczek, FR ;

Fischer, NH ;

Adams, LB ;

Franzblau, SG .

JOURNAL OF NATURAL PRODUCTS, 1996, 59 (12) :1131-1136

[3]

COHN DL, 1997, CLIN INFECT DIS S1, V24, P121

[4]

Collins LA, 1998, ANTIMICROB AGENTS CH, V42, P344

[5] Microplate Alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium [J].

Collins, LA ;

Franzblau, SG .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (05) :1004-1009

[6]

DUKE JA, 1985, CRC HDB MED HERBS, P65

[7]

FITZPATRICK FK, 1954, ANTIBIOT CHEMOTHER, V4, P528

[8] DETECTION OF ANTITUBERCULOUS ACTIVITY IN PLANT-EXTRACTS [J].

GRANGE, JM ;

DAVEY, RW .

JOURNAL OF APPLIED BACTERIOLOGY, 1990, 68 (06) :587-591

[9] BOTANICAL REMEDIES OF SOUTH AND CENTRAL AMERICA, AND THE CARIBBEAN - AN ARCHIVAL ANALYSIS .1. [J].

HIRSCHHORN, HH .

JOURNAL OF ETHNOPHARMACOLOGY, 1981, 4 (02) :129-158

[10]

Inderlied C. B., 1996, ANTIBIOTICS LAB MED, P127

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