Cellular senescence: Mitotic clock or culture shock?

被引:608
作者
Sherr, CJ [1 ]
DePinho, RA
机构
[1] St Jude Childrens Res Hosp, Howard Hughes Med Inst, Memphis, TN 38105 USA
[2] St Jude Childrens Res Hosp, Dept Tumor Cell Biol, Memphis, TN 38105 USA
[3] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA
[4] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA
[5] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA
关键词
D O I
10.1016/S0092-8674(00)00046-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
[No abstract available]
引用
收藏
页码:407 / 410
页数:4
相关论文
共 20 条
[1]   Telomere shortening and tumor formation by mouse cells lacking telomerase RNA [J].
Blasco, MA ;
Lee, HW ;
Hande, MP ;
Samper, E ;
Lansdorp, PM ;
DePinho, RA ;
Greider, CW .
CELL, 1997, 91 (01) :25-34
[2]   Extension of life-span by introduction of telomerase into normal human cells [J].
Bodnar, AG ;
Ouellette, M ;
Frolkis, M ;
Holt, SE ;
Chiu, CP ;
Morin, GB ;
Harley, CB ;
Shay, JW ;
Lichtsteiner, S ;
Wright, WE .
SCIENCE, 1998, 279 (5349) :349-352
[3]   p16INK4A and p19ARF act in overlapping pathways in cellular immortalization [J].
Carnero, A ;
Hudson, JD ;
Price, CM ;
Beach, DH .
NATURE CELL BIOLOGY, 2000, 2 (03) :148-155
[4]   p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis [J].
Chin, L ;
Artandi, SE ;
Shen, Q ;
Tam, A ;
Lee, SL ;
Gottlieb, GJ ;
Greider, CW ;
DePinho, RA .
CELL, 1999, 97 (04) :527-538
[5]   Telomeres, telomerase and cancer [J].
Greider, CW ;
Blackburn, EH .
SCIENTIFIC AMERICAN, 1996, 274 (02) :92-97
[6]   The hallmarks of cancer [J].
Hanahan, D ;
Weinberg, RA .
CELL, 2000, 100 (01) :57-70
[7]   SERIAL CULTIVATION OF HUMAN DIPLOID CELL STRAINS [J].
HAYFLICK, L ;
MOORHEAD, PS .
EXPERIMENTAL CELL RESEARCH, 1961, 25 (03) :585-+
[8]   Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19(ARF) [J].
Kamijo, T ;
Zindy, F ;
Roussel, MF ;
Quelle, DE ;
Downing, JR ;
Ashmun, RA ;
Grosveld, G ;
Sherr, CJ .
CELL, 1997, 91 (05) :649-659
[9]   p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2 [J].
Karlseder, J ;
Broccoli, D ;
Dai, YM ;
Hardy, S ;
de Lange, T .
SCIENCE, 1999, 283 (5406) :1321-1325
[10]   Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells [J].
Kiyono, T ;
Foster, SA ;
Koop, JI ;
McDougall, JK ;
Galloway, DA ;
Klingelhutz, AJ .
NATURE, 1998, 396 (6706) :84-88