Oligocarbonate Molecular Transporters: Oligomerization-Based Syntheses and Cell-Penetrating Studies

被引：110

作者：

Cooley, Christina B. ^{[2
,3
]}

Trantow, Brian M. ^{[2
,3
]}

Nederberg, Fredrik ^{[1
]}

Kiesewetter, Matthew K. ^{[2
,3
]}

Hedrick, James L. ^{[1
]}

Waymouth, Robert M. ^{[2
,3
]}

Wender, Paul A. ^{[2
,3
]}

机构：

[1] IBM Corp, Almaden Res Ctr, San Jose, CA 95120 USA

[2] Stanford Univ, Dept Chem & Syst Biol, Stanford, CA 94305 USA

[3] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 45期

基金：

美国国家卫生研究院;

关键词：

RING-OPENING POLYMERIZATION; DELIVERY VECTORS; DRUG-DELIVERY; INTERNALIZATION; PEPTIDES; MEMBRANE; ARGININE; DESIGN; CONJUGATION; ACTIVATION;

D O I：

10.1021/ja907363k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new family of guanidinium-rich molecular transporters featuring a novel oligocarbonate backbone with 1,7-side chain spacing is described. Conjugates can be rapidly assembled irrespective of length in a one-step oligomerization strategy that can proceed with concomitant introduction of probes (or by analogy drugs). The new transporters exhibit excellent cellular entry as determined by flow cytometry and fluorescence microscopy, and the functionality of their drug delivery capabilities was confirmed by the delivery of the bioluminescent small molecule probe luciferin and turnover by its intracellular target enzyme.

引用

页码：16401 / +

页数：5

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