Somatostatin receptor immunoreactivity in the eye of the adult newt (Pleurodeles waltlii Michan)

被引：6

作者：

Grigoryan, EN

Vasilaki, A

Mastrodimou, N

Thermos, K ^{[1
]}

机构：

[1] Univ Crete, Fac Med, Dept Basic Sci, Pharmacol Lab, Iraklion 71110, Crete, Greece

[2] Russian Acad Sci, Inst Dev Biol, Moscow 117808, Russia

来源：

NEUROSCIENCE LETTERS | 2003年 / 337卷 / 03期

关键词：

somatostatin; neuropeptide; photoreceptors; retina; immunohistochemistry;

D O I：

10.1016/S0304-3940(02)01326-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The neuropeptide somatostatin is found in the retina of many species, yet its role in the visual process remains to be elucidated. The aim of the present study was to examine the expression and cellular localization of somatostatin receptor subtypes (sst; sst(2A), sst(2B) and sst(3)) in the eye of the adult newt Pleurodeles waltlii using immunohistochemistry. sst(2A) immunoreactivity was observed in bipolar cells, in the inner segments of cone photoreceptors, as well as in the region corresponding to connecting cilia of rods. sst2B immunoreactivity was not detected. sst(3) immunostaining was localized most intensely in the inner segments of cones, and in cilia of rods. These results suggest that somatostatin acting via sst(2A) and sst(3) receptors may play an important role in retinal physiology of the lower vertebrates. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：143 / 146

页数：4

共 22 条

[1] Somatostatin modulates voltage-gated K+ and Ca2+ currents in rod and cone photoreceptors of the salamander retina [J].