Anaemia characterises patients with myelofibrosis harbouring MplW515L/K mutation

被引:121
作者
Guglielmelli, Paola
Pancrazzi, Alessandro
Bergamaschi, Gaetano
Rosti, Vittorio
Villani, Laura
Antonioli, Elisabetta
Bosi, Alberto
Barosi, Giovanni
Vannucchi, Alessandro M. [1 ]
机构
[1] Univ Florence, Dept Haematol, I-50134 Florence, Italy
[2] Policlin San Matteo, Lab Clin Epidemiol, Transplant Res Area, Unit Internal Med,Fdn Ist Ricovero & Cura Caratte, I-27100 Pavia, Italy
关键词
MPL mutation; myelofibrosis; JAK2(V617F); anaemia; myeloproliferative disorders;
D O I
10.1111/j.1365-2141.2007.06565.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The clinical and haematological phenotype of patients with myelofibrosis harbouring MPLW515L/K mutation has not been thoroughly investigated. Of 217 myelofibrosis subjects, 18 (8.2%) had an MPL mutation, four of which (22%) co-existed with JAK2(V617F) mutation. When compared with MPL wild-type patients, irrespective of JAK2(V617F) status, those with MPLW515L/K, were more frequently female, were older (61 years vs. 57 years; P = 0.02), presented with more severe anaemia (haemoglobin, 101 g/l vs. 121 g/l; P = 0.002) and were more likely to require regular transfusional support (P = 0.012). These data indicate that MPL mutation in myelofibrosis characterises patients with more severe anaemic phenotype.
引用
收藏
页码:244 / 247
页数:4
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