Vascular Calcification and ESRD: A Hard Target

被引：27

作者：

Bhan, Ishir ^{[1
]}

Thadhani, Ravi ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Dept Med, Div Nephrol, Boston, MA 02114 USA

来源：

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2009年 / 4卷

关键词：

CORONARY-ARTERY CALCIFICATION; STAGE RENAL-DISEASE; D-RECEPTOR ACTIVATORS; PULSE-WAVE VELOCITY; VITAMIN-D LEVELS; HEMODIALYSIS-PATIENTS; AORTIC CALCIFICATION; CALCIUM ACETATE; UREMIC RATS; ALL-CAUSE;

D O I：

10.2215/CJN.04800709

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

End-stage renal disease (ESRD) is associated with both accelerated cardiovascular disease and alterations in vitamin D and mineral metabolism. Calcification of both coronary and extra-cardiac vessels is common in ESRD. Several studies suggest that vascular calcification is associated with coronary atherosclerosis, vascular wall stiffness, left ventricular hypertrophy, and subsequent increased mortality, but it is not yet clear if vascular calcification is a direct cause of these changes or merely a marker of disease. Reviewed here is the current state of research on the biology and the significance of vascular calcification in ESRD, the role of vitamin D therapy in its development, and options for management. Clin J Am Soc Nephrol 4: S102-S105, 2009. doi: 10.2215/CJN.04800709

引用

页码：S102 / S105

页数：4

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