Picornavirus RNA translation: roles for cellular proteins

被引:109
作者
Belsham, GJ [1 ]
Sonenberg, N
机构
[1] BBSRC Inst Anim Hlth, Woking GU24 0NF, Surrey, England
[2] McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada
[3] McGill Univ, McGill Canc Ctr, Montreal, PQ H3G 1Y6, Canada
关键词
D O I
10.1016/S0966-842X(00)01788-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Picornavirus RNA is translated within cells even when cellular cap-dependent protein synthesis is blocked. The efficiency of recognition of the viral RNA by the translational apparatus can determine viral tropism. The roles of cellular translation-initiation factors and other RNA-binding proteins in viral RNA-mediated protein synthesis are discussed.
引用
收藏
页码:330 / 335
页数:6
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