The NK-2 homeobox gene scarecrow (scro) is expressed in pharynx, ventral nerve cord and brain of Drosophila embryos

被引：28

作者：

Zaffran, S ^{[1
]}

Das, G ^{[1
]}

Frasch, M ^{[1
]}

机构：

[1] Mt Sinai Sch Med, Dept Biochem & Mol Biol, New York, NY 10029 USA

来源：

MECHANISMS OF DEVELOPMENT | 2000年 / 94卷 / 1-2期

基金：

美国国家卫生研究院;

关键词：

Drosophila; homeodomain; NK-2; pharynx; central nervous system; optic lobe;

D O I：

10.1016/S0925-4773(00)00298-7

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Members of the NK homeobox family have been widely conserved during evolution. Here we describe the sequence and expression of a novel Drosophila NK-2 homeobox gene, named scarecrow (scro), which shows considerable homology to vertebrate Nkx-2.1. During embryogenesis, sere expression is initially observed in the pharyngeal primordia and later maintained in the pharynx. During band germ retraction, sere expression appears in two bilateral clusters of procephalic neuroblasts that give rise to distinct neuronal clusters in the brain. In addition, sere expression is observed in segmental clusters of neuronal precursors in the ventral nerve cord. In larval stages, sere expression occurs in portions of the optic lobe regions. These observations indicate that sere and vertebrate Nkx2.1 share similarities both in terms of their sequence and their expression patterns. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：237 / 241

页数：5

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