Correlation between near-infrared spectroscopy and magnetic resonance imaging of rat brain oxygenation modulation

被引：33

作者：

Chen, Y ^{[1
]}

Dharmesh, RT

Intes, X

Chance, B

机构：

[1] Univ Penn, Dept Biochem & Biophys, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA

[3] Univ Calif Los Angeles, Sch Med, Los Angeles, CA 90095 USA

来源：

PHYSICS IN MEDICINE AND BIOLOGY | 2003年 / 48卷 / 04期

关键词：

D O I：

10.1088/0031-9155/48/4/301

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

We measure the tissue oxygen and haemoglobin concentrations in the rat brain during modulation of inhaled oxygen concentration (FiO(2)), using non-invasive frequency domain near-infrared oximetry. The rise in oxygenated haemoglobin concentration and the decline in deoxygenated haemoglobin concentration are demonstrated in correspondence with the modulation of FiO(2), which is changed from 20% to 100% in increments of 20%. Furthermore, the tissue oxygenation saturation also shows the corresponding trend and changes ranging from approximately 70% to 90%. The relative changes in deoxygenated haemoglobin concentration are compared to the blood-oxygenation-level-dependent (BOLD) MRI signal recorded during a similar FiO(2) protocol. A linear relationship with high correlation coefficient between the relative changes in the BOLD MRI signal and the LAIRS signal is observed.

引用

页码：417 / 427

页数：11

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