Regulation of angiogenesis by hypoxia: role of the HIF system

被引：1939

作者：

Pugh, CW

Ratcliffe, PJ

机构：

[1] Henry Wellcome Building of Genomic Medicine, Oxford, OX3 7BN, Roosevelt Drive

来源：

NATURE MEDICINE | 2003年 / 9卷 / 06期

关键词：

D O I：

10.1038/nm0603-677

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The regulation of angiogenesis by hypoxia is an important component of homeostatic mechanisms that link vascular oxygen supply to metabolic demand. Molecular characterization of angiogenic pathways, identification of hypoxia-inducible factor (HIF) as a key transcriptional regulator of these molecules, and the definition of the HIF hydoxylases as a family of dioxygenases that regulate HIF in accordance with oxygen availability have provided new insights into this process. Here we review these findings, and the role of HIF in developmental, adaptive and neoplastic angiogenesis. We also discuss the implications of oncogenic activation of extensive, physiologically interconnected hypoxia pathways for the tumor phenotype.

引用

页码：677 / 684

页数：8

共 117 条

[1]

Alarcón R, 1999, CANCER RES, V59, P6046

[2]

Aravind L., 2001, GENOME BIOL, V2, p7.1

[3] EFFECT OF OXYGEN ON DEVELOPING RETINAL VESSELS WITH PARTICULAR REFERENCE TO THE PROBLEM OF RETROLENTAL FIBROPLASIA [J].