Caspases as regulators of apoptosis and other cell functions

被引：126

作者：

Philchenkov, AA ^{[1
]}

机构：

[1] Natl Acad Sci Ukraine, Kavetsky Inst Expt Pathol Oncol & Radiobiol, UA-03022 Kiev, Ukraine

来源：

BIOCHEMISTRY-MOSCOW | 2003年 / 68卷 / 04期

关键词：

caspases; apoptosis; caspase inhibitors; adaptor proteins; cytokines; cell proliferation; cell differentiation; cytoskeleton integrity;

D O I：

10.1023/A:1023635510363

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

This review covers current knowledge on the involvement in apoptosis of a new family of endopeptidases denoted as caspases. Their structure, specific substrates, and inhibitors are considered. The recent classification of cysteine proteases of the caspase family based on their structural and functional features is presented. The biological significance of caspases not related to their proapoptotic effect is discussed.

引用

页码：365 / 376

页数：12

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