Lipophilicity parameters for ionic liquid cations and their correlation to in vitro cytotoxicity

被引：283

作者：

Ranke, Johannes

Mueller, Anja

Bottin-Weber, Ulrike

Stock, Frauke

Stolte, Stefan

Arning, Juergen

Stoermann, Reinhold

Jastorff, Bernd

机构：

[1] Univ Bremen, Dept Bioorgan Chem, UFT Ctr Environm Sci & Technol, D-28359 Bremen, Germany

[2] Umweltbundesamt, D-06813 Dessau, Germany

来源：

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | 2007年 / 67卷 / 03期

关键词：

ionic liquids; lipophilicity; hydrophobicity; neoteric solvents; cytotoxicity; leukemia cell lines;

D O I：

10.1016/j.ecoenv.2006.08.008

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Regarding the great structural variability of the currently expanding group of ionic liquids, it is highly desirable to understand the basic factors affecting their toxicity in different biological systems. The present study of a set of 74 ionic liquids with imidazolium, pyrrolidinium, pyridinium, quinolinium, quaternary phosphonium and quaternary ammonium cations and the comparatively small anions Cl-, Br-, BF4-, or PF6- demonstrates the influence of the cation lipophilicity on the cytotoxicity in IPC-81 leukemia cells from rats. The scope of this correlation is limited to ionic liquids with these or similarly small anions that are sufficiently nonreactive under physiological and chromatographic conditions and whose cation lipophilicity does not exceed a certain threshold. (C) 2006 Elsevier Inc. All rights reserved.

引用

页码：430 / 438

页数：9

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