Capsular polysaccharide-fimbrial protein conjugate vaccine protects against Porphyromonas gingivalis infection in SCID mice reconstituted with human peripheral blood lymphocytes

被引：25

作者：

Choi, JI

Schifferle, RE

Yoshimura, F

Kim, BW

机构：

[1] Univ Rochester, Sch Med & Dent, Dept Pediat, Div Pediat Immunol, Rochester, NY 14642 USA

[2] SUNY Buffalo, Dept Oral Biol, Buffalo, NY 14214 USA

[3] SUNY Buffalo, Dept Periodontol, Buffalo, NY 14214 USA

[4] Aichi Gakuin Univ, Dept Microbiol, Nagoya, Aichi 464, Japan

[5] Dongeui Univ, Dept Microbiol, Pusan 614714, South Korea

来源：

INFECTION AND IMMUNITY | 1998年 / 66卷 / 01期

关键词：

D O I：

10.1128/IAI.66.1.391-393.1998

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The effect of immunization with either a Porphyromonas gingivalis fimbrial protein, a capsular polysaccharide, or a capsular polysaccharide-fimbrial protein conjugate vaccine were compared in hu-PBL-SCID mice. A significantly higher human immunoglobulin G antibody response and the highest degree of in vivo protection against bacterial challenge was observed in the group immunized with the conjugate vaccine. It was concluded that capsular polysaccharide-fimbrial protein conjugate from P. gingivalis could potentially be developed as a vaccine against periodontal infection by P. gingivalis.

引用

页码：391 / 393

页数：3

共 15 条

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