Autophagy and tumorigenesis

被引：172

作者：

Chen, Nan ^{[1
]}

Debnath, Jayanta ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Pathol, Diller Comprehens Canc Ctr, San Francisco, CA 94143 USA

来源：

FEBS LETTERS | 2010年 / 584卷 / 07期

关键词：

Autophagy; Cancer; Genome instability; Cell death; Chemotherapy; TUBEROUS SCLEROSIS COMPLEX; MALIGNANT GLIOMA-CELLS; BREAST-CANCER CELLS; BCL-X-L; TUMOR-SUPPRESSOR; BECLIN; PHOSPHATIDYLINOSITOL; 3-KINASE; MICROSATELLITE INSTABILITY; INDUCED CYTOTOXICITY; REGULATES AUTOPHAGY;

D O I：

10.1016/j.febslet.2009.12.034

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Autophagy, or cellular self-digestion, is activated in cancer cells in response to multiple stresses and has been demonstrated to promote tumor cell survival and drug resistance. Nonetheless, genetic evidence supports that autophagy functions as a tumor suppressor mechanism. Hence, the precise role of autophagy during cancer progression and treatment is both tissue and context dependent. Here, we discuss our current understanding of the biological functions of autophagy during cancer development, overview how autophagy is regulated by cancer-associated signaling pathways, and review how autophagy inhibition is being exploited to improve clinical outcomes. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：1427 / 1435

页数：9

共 94 条

[1]

Autophagy delays apoptotic death in breast cancer cells following DNA damage [J].

Abedin, M. J. ;

Wang, D. ;

McDonnell, M. A. ;

Lehmann, U. ;

Kelekar, A. .

CELL DEATH AND DIFFERENTIATION, 2007, 14 (03) :500-510

[2]

Silencing of Bcl-2 expression by small interfering RNA induces autophagic cell death in MCF-7 breast cancer cells [J].

Akar, Ugur ;

Chaves-Reyez, Arturo ;

Barria, Magaly ;

Tari, Ana ;

Sanguino, Angela ;

Kondo, Yasuko ;

Kondo, Seiji ;

Arun, Banu ;

Lopez-Berestein, Gabriel ;

Ozpolat, Bulent .

AUTOPHAGY, 2008, 4 (05) :669-679

[3]

Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma [J].

Amaravadi, Ravi K. ;

Yu, Duonan ;

Lum, Julian J. ;

Bui, Thi ;

Christophorou, Maria A. ;

Evan, Gerard I. ;

Thomas-Tikhonenko, Andrei ;

Thompson, Craig B. .

JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (02) :326-336

[4]

Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy [J].

Apel, Anja ;

Herr, Ingrid ;

Schwarz, Heinz ;

Rodemann, H. Peter ;

Mayer, Andreas .

CANCER RESEARCH, 2008, 68 (05) :1485-1494

[5]

The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway [J].

Arico, S ;

Petiot, A ;

Bauvy, C ;

Dubbelhuis, PF ;

Meijer, AJ ;

Codogno, P ;

Ogier-Denis, E .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (38) :35243-35246

[6]

Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells [J].

Bellodi, Cristian ;

Lidonnici, Maria Rosa ;

Hamilton, Ashley ;

Helgason, G. Vignir ;

Soliera, Angela Rachele ;

Ronchetti, Mattia ;

Galavotti, Sara ;

Young, Kenneth W. ;

Selmi, Tommaso ;

Yacobi, Rinat ;

Van Etten, Richard A. ;

Donato, Nick ;

Hunter, Ann ;

Dinsdale, David ;

Tirro, Elena ;

Vigneri, Paolo ;

Nicotera, Pierluigi ;

Dyer, Martin J. ;

Holyoake, Tessa ;

Salomoni, Paolo ;

Calabretta, Bruno .

JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (05) :1109-1123

[7]

The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies [J].

Bingle, L ;

Brown, NJ ;

Lewis, CE .

JOURNAL OF PATHOLOGY, 2002, 196 (03) :254-265

[8]

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death [J].

Bjorkoy, G ;

Lamark, T ;

Brech, A ;

Outzen, H ;

Perander, M ;

Overvatn, A ;

Stenmark, H ;

Johansen, T .

JOURNAL OF CELL BIOLOGY, 2005, 171 (04) :603-614

[9]

p53 target genes Sestrin1 and Sestrin2 connect genotoxic stress and mTOR signaling [J].

Budanov, Andrei V. ;

Karin, Michael .

CELL, 2008, 134 (03) :451-460

[10]

Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance [J].

Carew, Jennifer S. ;

Nawrocki, Steffan T. ;

Kahue, Charissa N. ;

Zhang, Hui ;

Yang, Chunying ;

Chung, Linda ;

Houghton, Janet A. ;

Huang, Peng ;

Giles, Francis J. ;

Cleveland, John L. .

BLOOD, 2007, 110 (01) :313-322

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