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A novel alternative spliced variant of neutrophil gelatinase-associated lipocalin receptor in oesophageal carcinoma cells

被引：41
作者：
Fang, Wang-Kai
Xu, Li-Yan [1 ]
Lu, Xiao-Feng
Liao, Lian-Di
Cai, Wei-Jia
Shen, Zhong-Ying
Li, En-Min
机构：
[1] Shantou Univ, Coll Med, Dept Biochem & Mol Biol, Shantou 515041, Guangdong, Peoples R China
[2] Shantou Univ, Coll Med, Dept Pathol, Key Immunopathol Lab Guangdong Province, Shantou 515041, Guangdong, Peoples R China
来源：
BIOCHEMICAL JOURNAL | 2007年 / 403卷 / 297-303期
关键词：
iron transport; lipocalin; neutrophil gelatinase-associated lipocalin (NGAL); NgalR-3; oesophageal carcinoma;
D O I：
10.1042/BJ20060836
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent studies suggest that NGAL (neutrophil gelatinase-associated lipocalin) is a novel iron transporter with functions distinct from that of transferrin and mediates a new iron-delivery pathway. To get a better understanding of NGAL function in oesophageal carcinoma, we analysed the expression of NGAL receptors in oesophageal carcinoma cells and identified a novel spliced variant designated NgalR-3. When expressed in a heterologous system, the protein produced from this novel spliced variant exhibits the biochemical characteristics of interaction and co-localization with NGAL protein in vivo. This new finding suggests that NgalR-3 may act as a potential NGAL receptor and play a role in NGAL-mediated iron transport in oesophageal carcinoma.
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收藏
页码：297 / 303
页数：7
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