Antitumor effect induced by the expression of granulocyte macrophage-colony stimulating factor gene in murine colon carcinoma cells

被引：14

作者：

Gunji, Y

Tagawa, M

Matsubara, H

Takenaga, K

Shimada, H

Kondo, F

Suzuki, T

Nakajima, K

Sugaya, M

Asano, T

Ochiai, T

Isono, K

Horitsu, K

Kageyama, H

Nakamura, Y

Sakiyama, S

机构：

[1] CHIBA UNIV,SCH MED,DEPT BIOCHEM,CHUO KU,CHIBA 260,JAPAN

[2] CHIBA UNIV,SCH MED,DEPT SURG 2,CHUO KU,CHIBA 260,JAPAN

[3] CHIBA UNIV,SCH MED,DEPT PATHOL,CHUO KU,CHIBA 260,JAPAN

[4] CHIBA CANC RES INST,DIV CHEMOTHERAPY,CHUO KU,CHIBA 260,JAPAN

[5] TOKYO KASEI UNIV,FAC HOME ECON,ITABASHI KU,TOKYO 173,JAPAN

来源：

CANCER LETTERS | 1996年 / 101卷 / 02期

关键词：

cytokine; gene therapy; colon tumor;

D O I：

10.1016/0304-3835(96)04141-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Murine colon carcinoma cells which secrete several kinds of cytokine after retroviral transduction with corresponding genes, were examined for their antitumor effects in syngeneic mice. The mice inoculated with granulocyte macrophage-colony stimulating factor (GM-CSF) producer cells showed not only prolonged survival but also reduced tumorigenicity. The antitumor effect caused by the expression of interleukin-4 was less than that of GM-CSF, and interleukin-6 producer cells did not show any effects on the survival of the host animals. Histological examination of the GM-CSF-producing tumor revealed predominant infiltration of neutrophils and necrotic change of the tumor. The present study indicates the feasibility of cancer gene therapy with the expression of GM-CSF gene in tumor cells.

引用

页码：257 / 261

页数：5

共 27 条

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