Matrix metalloproteinases: A therapeutic target in cardiovascular disease

Cardiovascular disease is the leading cause of death in Western society. Extracellular matrix turnover is L important in many cardiovascular pathologies, such as arterial remodeling. plaque rupture, restenosis, aneurysm formation and heart failure. Matrix metalloproteinases (MMPs) belong to a group of zinc and calcium dependent proteases and cause breakdown of the extracellular matrix. MMP inhibitors have been developed and tested for their effect on the outcome of oncological disease [1]. Recent preclinical research revealed that these MMP inhibitors could also have great potential in the field of cardiovascular disease. This preclinical research has encouraged investigators to design and start the First clinical studies with cardiovascular endpoints. In the present paper, the various aspects of MMP participation in cardiovascular disease will be summarized. Preclinical demonstrated the effect and potential of applicable MMP inhibitors on different cardiovascular disease animal studies that entities will be discussed. We Will specifically focus Oil the role of MMPs and the potential of their inhibitors in de novo remodeling, restenosis after ballon angioplasty and stenting, aneurysm atherosclerotic plaque destabilization, arterial formation and heart failure. We Conclude that MMP inhibitors are likely to be useful in the development of pharmacological approaches to reduce cardiovascular death. considering file positive Outcomes after usage of MMP inhibitors in restenosis and arterial remodeling.