A human transforming growth factor-beta type II receptor that contains an insertion in the extracellular domain

被引:28
作者
Hirai, R
Fujita, T
机构
[1] Tokyo Metropol. Inst. of Med. Sci., Tokyo
[2] Tokyo Metropol. Inst. of Med. Sci., Tokyo 113, Honkomagome 3-18-22, Bunkyo-ku
关键词
D O I
10.1006/excr.1996.0066
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
In the signal transduction of transforming growth factor-beta (TGF-beta), the TGF-beta type II receptor (beta R-II) binds TGF-beta, presents the ligand to type I receptor, and forms a heterodimeric receptor complex that functions as an active signaling receptor. We isolated cDNA clones encoding an isoform of human beta R-II from vascular endothelial cells by RT-PCR. The deduced structure of the isoform designated as beta R-IIb contained a 25-amino acid residue inserted at the extracellular region. The insert exhibited 73% homology to a similar insertion found in a mouse beta R-II variant. beta R-IIb mRNA was ubiquitously expressed in all human cell lines examined. beta R-IIb as well as beta R-II stably expressed in beta RII-deficient DR26 cells acted as a functional receptor transducing signals from TGF-beta for growth inhibition and the transcriptional activation of the plasminogen activator inhibitor-1 promoter. These results indicated that the beta R-IIb expressed in mammalian cells functions indistinguishably from beta R-II. The potential function of beta R-IIb is discussed. (C) 1996 Academic Press, Inc.
引用
收藏
页码:135 / 141
页数:7
相关论文
共 32 条
  • [1] AN ASSAY FOR TRANSFORMING GROWTH-FACTOR-BETA USING CELLS TRANSFECTED WITH A PLASMINOGEN-ACTIVATOR INHIBITOR-1 PROMOTER LUCIFERASE CONSTRUCT
    ABE, M
    HARPEL, JG
    METZ, CN
    NUNES, I
    LOSKUTOFF, DJ
    RIFKIN, DB
    [J]. ANALYTICAL BIOCHEMISTRY, 1994, 216 (02) : 276 - 284
  • [2] NOVEL ACTIVIN RECEPTORS - DISTINCT GENES AND ALTERNATIVE MESSENGER-RNA SPLICING GENERATE A REPERTOIRE OF SERINE THREONINE KINASE RECEPTORS
    ATTISANO, L
    WRANA, JL
    CHEIFETZ, S
    MASSAGUE, J
    [J]. CELL, 1992, 68 (01) : 97 - 108
  • [3] CHEIFETZ S, 1990, J BIOL CHEM, V265, P20533
  • [4] CHEN RH, 1994, J BIOL CHEM, V269, P22868
  • [5] A NEW TYPE OF TRANSFORMING GROWTH FACTOR-BETA, TGF-BETA-3
    DERYNCK, R
    LINDQUIST, PB
    LEE, A
    WEN, D
    TAMM, J
    GRAYCAR, JL
    RHEE, L
    MASON, AJ
    MILLER, DA
    COFFEY, RJ
    MOSES, HL
    CHEN, EY
    [J]. EMBO JOURNAL, 1988, 7 (12) : 3737 - 3743
  • [6] CLONING, EXPRESSION, AND ALTERNATIVE SPLICING OF THE RECEPTOR FOR ANTI-MULLERIAN HORMONE
    DICLEMENTE, N
    WILSON, C
    FAURE, E
    BOUSSIN, L
    CARMILLO, P
    TIZARD, R
    PICARD, JY
    VIGIER, B
    JOSSO, N
    CATE, R
    [J]. MOLECULAR ENDOCRINOLOGY, 1994, 8 (08) : 1006 - 1020
  • [7] CLONING OF A TGF-BETA TYPE-I RECEPTOR THAT FORMS A HETEROMERIC COMPLEX WITH THE TGF-BETA TYPE-II RECEPTOR
    FRANZEN, P
    TENDIJKE, P
    ICHIJO, H
    YAMASHITA, H
    SCHULZ, P
    HELDIN, CH
    MIYAZONO, K
    [J]. CELL, 1993, 75 (04) : 681 - 692
  • [8] TRANSFORMING GROWTH FACTOR-BETA-1-SPECIFIC BINDING-PROTEINS ON HUMAN VASCULAR ENDOTHELIAL-CELLS
    HIRAI, R
    KAJI, K
    [J]. EXPERIMENTAL CELL RESEARCH, 1992, 201 (01) : 119 - 125
  • [9] HIRAI R, 1992, TISSUE CULT RES COMM, V11, P317
  • [10] COMPARISON OF THE BIOLOGICAL ACTIONS OF TGF BETA-1 AND TGF BETA-2 - DIFFERENTIAL ACTIVITY IN ENDOTHELIAL-CELLS
    JENNINGS, JC
    MOHAN, S
    LINKHART, TA
    WIDSTROM, R
    BAYLINK, DJ
    [J]. JOURNAL OF CELLULAR PHYSIOLOGY, 1988, 137 (01) : 167 - 172