Transcriptional repression by Myc

被引：161

作者：

Wanzel, M ^{[1
]}

Herold, S ^{[1
]}

Eilers, M ^{[1
]}

机构：

[1] Univ Marburg, Inst Mol Biol & Tumor Res, D-35033 Marburg, Germany

来源：

TRENDS IN CELL BIOLOGY | 2003年 / 13卷 / 03期

关键词：

D O I：

10.1016/S0962-8924(03)00003-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Myc oncoprotein is a transcription factor that can both activate and repress genes. Transcriptional activation by Myc is well understood, but, by contrast, the mechanisms through which Myc represses transcription have remained elusive. Recent evidence suggests that complex formation by Myc with a zinc-finger transcription factor, Miz-1, plays an important role in mediating repression by Myc. The findings might explain how Myc interferes with cell-cycle arrest in response to TGF-beta, APC and DNA damage.

引用

页码：146 / 150

页数：5

共 56 条

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