The ovary: basic biology and clinical implications

被引：467

作者：

Richards, JoAnne S. ^{[1
]}

Pangas, Stephanie A. ^{[2
]}

机构：

[1] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Pathol, Houston, TX 77030 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2010年 / 120卷 / 04期

关键词：

CACHEXIA-LIKE SYNDROME; OOCYTE NEST BREAKDOWN; GRANULOSA-CELLS; POLYOVULAR FOLLICLES; NEONATAL EXPOSURE; GENE-EXPRESSION; MOUSE OVARY; STEROIDOGENIC FACTOR-1; FOLLICULAR DEVELOPMENT; REPRODUCTIVE-TRACT;

D O I：

10.1172/JCI41350

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

The classical view of ovarian follicle development is that it is regulated by the hypothalamic-pituitary-ovarian axis, in which gonadotropin-releasing hormone (GnRH) controls the release of the gonadotropic hormones follicle-stimulating hormone (FSH) and luteinizing hormone (LH), and that ovarian steroids exert both negative and positive regulatory effects on GnRH secretion. More recent studies in mice and humans indicate that many other intra-ovarian signaling cascades affect follicular development and gonadotropin action in a stage- and context-specific manner. As we discuss here, mutant mouse models and clinical evidence indicate that some of the most powerful intra-ovarian regulators of follicular development include the TGF-beta/SMAD, WNT/FZD/beta-catenin, and RAS/ERK1/2 signaling pathways and the FOXO/FOXL2 transcription factors.

引用

页码：963 / 972

页数：10

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