Asymptomatic Dengue Infection in a Cuban Population Confirms the Protective Role of the RR Variant of the FcγRIIa Polymorphism

被引：75

作者：

Garcia, Gissel ^{[1
]}

Sierra, Beatriz ^{[1
]}

Perez, Ana B. ^{[1
]}

Aguirre, Eglys ^{[1
]}

Rosado, Ileana ^{[2
]}

Gonzalez, Narjara ^{[3
]}

Izquierdo, Alienys ^{[1
]}

Pupo, Maritza

Ruiz, Didye ^{[1
]}

Diaz, Danay ^{[1
]}

Sanchez, Lizet ^{[4
]}

Marcheco, Beatriz

Hirayama, Kenji ^{[5
]}

Guzman, Maria G. ^{[1
]}

机构：

[1] Trop Med Inst Pedro Kouri, Dept Virol, Havana, Cuba

[2] Med Genet Natl Ctr, Dept Mol Biol, Havana, Cuba

[3] Mol Immunol Ctr, Dept Qual Control, Havana, Cuba

[4] Trop Med Inst Pedro Kouri, Dept Epidemiol, Havana, Cuba

[5] Nagasaki Univ, Global Ctr Excellence Program, Inst Trop Med NEKKEN, Nagasaki 852, Japan

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 2010年 / 82卷 / 06期

关键词：

HEMORRHAGIC-FEVER; RECEPTOR; ASSOCIATION; SUSCEPTIBILITY; DISEASE; HLA; AFFINITY; DOMAIN;

D O I：

10.4269/ajtmh.2010.09-0353

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The role of human Fc gamma receptors (Fc gamma R) has been recognized considerably over the last years. These receptors vary in their affinity for IgG subclasses and the intracellular signals elicited by them. Allelic variants of Fc gamma R genes may influence the biological phagocyte activity, accounting for an inherited pre-disposition to disease. The specific Fc gamma RIIa (CD32) contains a polymorphic variant (H/R131) that has been associated to a reduced risk for developing dengue hemorrhagic fever (DHF). Here, we investigated the role of this polymorphism in a very well-characterized group of Cuban individuals with antecedents of DHF, dengue fever (DF), or subclinical dengue infection. The HH131 genotype was significantly associated with dengue disease, either DF (*P = 0.016; odds ratio = 4.425; 95% confidence interval = 1.10-20.52) or DHF (P = 0.00018; odds ratio = 10.56; 95% confidence interval = 2.33-54.64) with respect to the subclinical infection.

引用

页码：1153 / 1156

页数：4

共 30 条

[1] FcγRIIa polymorphism:: a susceptibility factor for immune complex-mediated lupus nephritis in Brazilian patients [J].