Total synthesis of (+)-phomactin A using a B-alkyl Suzuki macrocyclization

被引：119

作者：

Mohr, PJ ^{[1
]}

Halcomb, RL ^{[1
]}

机构：

[1] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 07期

关键词：

D O I：

10.1021/ja0296531

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A total synthesis of (+)-phomactin A is described using a B-alkyl Suzuki macrocyclization to incorporate the isolated trisubstituted olefin. This macrocyclization was accomplished with the sensitive hydrated furan ring in place. (R)-(+)-pulegone was used to establish the highly substituted cyclohexene core of the molecule. Copyright © 2003 American Chemical Society.

引用

页码：1712 / 1713

页数：2

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