New β-carboline alkaloids from the andaman sea sponge Dragmacidon sp.

Chemical investigation of the hithertho undescribed sponge Dragmacidon sp. from the Andaman Sea afforded two new beta-carboline alkaloids, which were named dragmacidonamines A (1) and B (2). The structures of the new compounds were unambiguously established on the basis of NMR spectroscopic (H-1, C-13, COSY, H-1 detected direct, and long-range C-13-H-1 correlations) and mass spectrometric (EI and ESIMS) data. The 3-carboxylic-beta-carboline moiety and the thiomethylated imidazolinium unit as found in dragmacidonamines are very rarely encountered in nature.