Secu'amamine A, a novel indolizidine alkaloid from Securinega suffruticosa var. amamiensis

被引：38

作者：

Ohsaki, A ^{[1
]}

Ishiyama, H

Yoneda, K

Kobayashi, J

机构：

[1] Tokyo Med & Dent Univ, Inst Biomat & Bioengn, Tokyo 1010062, Japan

[2] Hokkaido Univ, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan

[3] Osaka Univ, Grad Sch Pharmaceut Sci, Suita, Osaka 5650871, Japan

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 15期

关键词：

D O I：

10.1016/S0040-4039(03)00546-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

A novel indolizidine alkaloid, secu'amamine A (1), was isolated from the leaves and twigs of the medicinal plant Securinega suffruticosa var. amamiensis together with securinine (2). The structure and relative stereochemistry of 1 was elucidated by spectroscopic data and its absolute configuration was assigned on the basis of the OMe-madelate method. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：3097 / 3099

页数：3

共 12 条

[1]

ARABAIN D, 1991, J CHEMSOC P1, P1863

[2]

BEUTLER J A, 1987, Drugs of the Future, V12, P957

[3]

Dong NZ, 1999, ACTA PHARMACOL SIN, V20, P267

[4]

IDENTIFYING AGONISTIC AND ANTAGONISTIC MECHANISMS OPERATIVE AT THE GABA RECEPTOR [J].

GALVEZRUANO, E ;

APRISON, MH ;

ROBERTSON, DH ;

LIPKOWITZ, KB .

JOURNAL OF NEUROSCIENCE RESEARCH, 1995, 42 (05) :666-673

[5]

ISOLATION AND STRUCTURE (X-RAY-ANALYSIS) OF ENT-NORSECURININE, AN ALKALOID FROM PHYLLANTHUS-NIRURI [J].

JOSHI, BS ;

GAWAD, DH ;

PELLETIER, SW ;

KARTHA, G ;

BHANDARY, K .

JOURNAL OF NATURAL PRODUCTS, 1986, 49 (04) :614-620

[6]

Subincanadines A-C, novel quaternary indole alkaloids from Aspidosperma subincanum [J].

Kobayashi, J ;

Sekiguchi, M ;

Shimamoto, S ;

Shigemori, H ;

Ishiyama, H ;

Ohsaki, A .

JOURNAL OF ORGANIC CHEMISTRY, 2002, 67 (18) :6449-6455

[7]

ANTIBACTERIAL ACTIVITY OF THE LEAVES OF PHYLLANTHUS-DISCOIDEUS [J].

MENSAH, JL ;

LAGARDE, I ;

CESCHIN, C ;

MICHEL, G ;

GLEYE, J ;

FOURASTE, I .

JOURNAL OF ETHNOPHARMACOLOGY, 1990, 28 (01) :129-133

[8]

STRUCTURE AND MOLECULAR MODELING OF GABA-A RECEPTOR ANTAGONISTS [J].

ROGNAN, D ;

BOULANGER, T ;

HOFFMANN, R ;

VERCAUTEREN, DP ;

ANDRE, JM ;

DURANT, F ;

WERMUTH, CG .

JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (11) :1969-1977

[9]

STRUCTURE OF SECURININE [J].

SAITO, S ;

YAMAWAKI, Y ;

KOTERA, K ;

IDE, A ;

SHIGEMATSU, N ;

HORII, Z ;

HANAOKA, M ;

SUGIMOTO, N ;

TAMURA, Y .

TETRAHEDRON, 1963, 19 (12) :2085-&

[10]

Snieckus V., 1975, ALKALOIDS, V14, P425

← 1 2 →