Differential regulation of the mcb and emr operons of Escherichia coli: Role of mcb in multidrug resistance

被引：26

作者：

Lomovskaya, O ^{[1
]}

Kawai, F ^{[1
]}

Matin, A ^{[1
]}

机构：

[1] STANFORD UNIV, SCH MED, DEPT MICROBIOL & IMMUNOL, STANFORD, CA 94305 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1996年 / 40卷 / 04期

关键词：

D O I：

10.1128/AAC.40.4.1050

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The mcb operon (which is responsible for microcin B17 production) and the emr operon (which encodes a multidrug resistance pump) share a common negative regulator, EmrR. Nevertheless, compounds that induce the emr operon repress the mcb operon, The pump dedicated to microcin B17 extrusion can also protect the cells against sparfloxacin and other toxic compounds.

引用

页码：1050 / 1052

页数：3

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