Neurotoxic effects of 25 mg/kg/bodyweight of artemether on the histology of the trapezoid nuclei and behavioural functions in adult male Wistar rats

被引：17

作者：

Akinlolu, Abdulazeez Adelaja ^{[1
]}

Shokunbi, Mathew Temitayo ^{[2
]}

机构：

[1] Olabisi Onabanjo Univ, Fac Basic Med Sci, Dept Anat, Ago Iwoye, Ogun State, Nigeria

[2] Univ Ibadan, Fac Basic Med Sci, Dept Anat, Ibadan, Oyo State, Nigeria

来源：

ACTA HISTOCHEMICA | 2010年 / 112卷 / 02期

关键词：

Artemether; Neurotoxicity; Brain weight; Trapezoid nuclei; Patchychromatic neurons; Behavioural functions; Wistar rats; ARTEMISININ DERIVATIVES; ARTEETHER; QINGHAOSU; TOXICITY; BRAIN;

D O I：

10.1016/j.acthis.2008.09.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

This study investigated the effects of the administration of 25 mg/kg/bodyweight of artemether for a period of 7 days on the trapezoid nuclei and behavioural functions in male Wistar rats. This was to establish the neurotoxic potential of artemether as an antimalarial drug. All rats showed normal morphological appearances at the completion of the experimental procedure. Statistical analyses showed no significant differences between the average brain weight of the control group and the experimental group. The assessment of brainstem nuclei showed patchychromatic appearance of neurons of the trapezoid nuclei in the experimental group as against the normal vesicular appearance of neurons of the trapezoid nuclei in the control group. The density of damaged trapezoid nuclei was significantly higher in the experimental group than in the control group. The rats in the control group displayed normal balance and coordination, white rats in the experimental group showed abnormalities in balance and coordination. This study observed that administration of 25 mg/kg/bodyweight of artemether for a period of 7 days had neurotoxic effects on the trapezoid nuclei of Wistar rats. (C) 2008 Elsevier GmbH. All rights reserved.

引用

页码：193 / 198

页数：6

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