A developmental switch in the excitability and function of the starburst network in the mammalian retina

被引:112
作者
Zheng, JJ
Lee, S
Zhou, ZJ [1 ]
机构
[1] Univ Arkansas Med Sci, Dept Physiol & Biophys, Little Rock, AR 72205 USA
[2] Univ Arkansas Med Sci, Dept Ophthalmol, Little Rock, AR 72205 USA
关键词
D O I
10.1016/j.neuron.2004.11.015
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Dual patch-clamp recording and Ca2+ uncaging revealed Ca2+-dependent corelease of ACh and GABA from, and the presence of reciprocal nicotinic and GABAergic synapses between, starburst cells in the perinatal rabbit retina. With maturation, the nicotinic synapses between starburst cells dramatically diminished, whereas the GABAergic synapses remained and changed from excitatory to inhibitory, indicating a coordinated conversion of the starburst network excitability from an early hyperexcitatory to a mature nonepileptic state. We show that this transition allows the starburst cells to use their neurotransmitters; for two completely different functions. During early development, the starburst network mediates recurrent excitation and spontaneous retinal waves, which are important for visual system development. After vision begins, starburst cells release GABA in a prolonged and Ca2+-dependent manner and inhibit each other laterally via direct GABAergic synapses, which may be important for visual integration, such as the detection of motion direction.
引用
收藏
页码:851 / 864
页数:14
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