Concurrence of histologic features of steatohepatitis with other forms of chronic liver disease

被引:128
作者
Brunt, EM
Ramrakhiani, S
Cordes, BG
Neuschwander-Tetri, BA
Janney, CG
Bacon, BR
Di Bisceglie, AM
机构
[1] St Louis Univ, Ctr Hlth Sci, Ctr Liver, Dept Internal Med, St Louis, MO 63103 USA
[2] St Louis Univ, Ctr Hlth Sci, Div Gastroenterol & Hepatol, St Louis, MO 63103 USA
[3] St Louis Univ, Ctr Hlth Sci, Ctr Liver, Dept Pathol, St Louis, MO 63103 USA
关键词
clinical correlations; concurrence with chronic liver disease; steatohepatitis;
D O I
10.1097/01.MP.0000042420.21088.C7
中图分类号
R36 [病理学];
学科分类号
100104 [病理学与病理生理学];
摘要
Steatohepatitis, of either alcoholic or nonalcoholic etiologies, is ultimately diagnosed by clinical-pathologic correlation and is characterized histologically by lesions that differ from the portal-based chronic inflammation and fibrosis of most other forms of chronic liver disease. With the increasing prevalence of steatohepatitis In our society, it is likely that some patients will have coexistent clinical and/or histopathologic findings of steatohepatitis concurrently with another form of liver disease. The aim of this study was to document clinical and histologic findings in biopsies in an academic referral center. Ninety-three non-allograft liver biopsies with lesions of both steatohepatitis and another liver disease were retrospectively identified in 85 patients. The finding of coexisting disease represented 5.5% of all hepatitis C biopsies and 4.0% of other forms of chronic liver disease in the 34 month time period. Clinical chart review of patients with concurrent disease showed the following: Group 1, patients with hepatitis C (n = 54); Group 2, patients with hepatitis C and prior or current history of more than 80 g/d alcohol consumption (n = 20); Group 3, patients with other forms of chronic liver disease (n = 11). Groups 1 and 3 had <10 g/d alcohol use. Obesity (body mass index >30) was noted in 75%, 60%, and 33% respectively, while 94%, 87% and 100% of patients were considered overweight (body mass index greater than or equal to 25). Diabetes was reported in 35%, 25%, and 9%. The concurrence of clinical and histologic features of steatohepatitis with another chronic liver disease may be a reflection of the frequency of steatohepatitis in the population at large.
引用
收藏
页码:49 / 56
页数:8
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