Solid-phase-assisted solution-phase synthesis with minimum purification-preparation of 2-deoxyglycoconjugates from thioglycosides

被引：29

作者：

Jaunzems, J

Hofer, E

Jesberger, M

Sourkouni-Argirusi, G

Kirschning, A

机构：

[1] Leibniz Univ Hannover, Inst Organ Chem, D-30167 Hannover, Germany

[2] Tech Univ Clausthal, Inst Organ Chem, D-38678 Clausthal Zellerfeld, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 10期

关键词：

functionalized polymers; glycosidation; separation techniques; solid-phase synthesis; thioglycosides;

D O I：

10.1002/anie.200390307

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Minimum effort - maximum effect: Deoxygenated oligosaccharides and glycoconjugates are prepared in high yields with minimum purification from thioglycosides (see scheme) by exclusively employing reagents that are removed by simple filtration. New solidphase-assisted synthetic protocols for removal of thiophenol and diphenyl disulfide are disclosed that make use of functionalized polymers. RO=testosteryl.

引用

页码：1166 / 1170

页数：5

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