Proton T2 relaxation of cerebral metabolites during transient global ischemia in rat brain

被引：13

作者：

Fujimori, H ^{[1
]}

Michaelis, T ^{[1
]}

Wick, M ^{[1
]}

Frahm, J ^{[1
]}

机构：

[1] Max Planck Inst Biophys Chem, Biomed NMR Forsch GMBH, D-37070 Gottingen, Germany

来源：

MAGNETIC RESONANCE IN MEDICINE | 1998年 / 39卷 / 04期

关键词：

brain ischemia; proton MRS; T-2; measurement; brain metabolites;

D O I：

10.1002/mrm.1910390419

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Putative changes of metabolite T-2 relaxation times were investigated before and after a 20-min period of global ischemia in rat brain in vivo (n = 10) using localized proton MRS at different echo times (2.35 T). Neither absolute T,relaxation times (TE = 20-270 ms) nor time courses of T-2-weighted metabolite signals (TE = 135 ms) revealed statistically significant changes during the occlusion or early reperfusion relative to pre-ischemic baseline. These findings are in line with reports of relaxation changes at much later stages and further demonstrate that altered T-2 relaxation is not a confounding factor in diffusion-weighted long-TE proton MRS during early ischemic events.

引用

页码：647 / 650

页数：4

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