New mechanoenergetic evaluation of left ventricular contractility in in situ rat hearts

被引:34
作者
Tachibana, H [1 ]
Takaki, M [1 ]
Lee, SY [1 ]
Ito, H [1 ]
Yamaguchi, H [1 ]
Suga, H [1 ]
机构
[1] OKAYAMA UNIV, DEPT PHYSIOL 2, SCH MED, OKAYAMA 700, JAPAN
来源
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 1997年 / 272卷 / 06期
关键词
end-systolic pressure-volume relationship; pressure-volume area; pressure-volume loop; propranolol; dobutamine;
D O I
10.1152/ajpheart.1997.272.6.H2671
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We recorded a series of ejecting left ventricular (LV) pressure (P)-volume (V) loops of in situ rat hearts during a gradual ascending aortic occlusion. The end-systolic (ES) P-V relationship (ESPVR) was upward convex curvilinear regardless of LV contractility. The ESPVR was shifted upward in an enhanced contractility by dobutamine and downward in a depressed contractility by propranolol; ESP at a midrange V of 0.1 ml/g LV on each ESPVR increased from 131 +/- 11 to 192 +/- 17 mmHg and decreased from 136 +/- 10 to 110 +/- 7 mmHg, respectively. Furthermore, we obtained an upward concave curvilinear pressure-volume area (PVA; a measure of total mechanical energy)-V (preload) relationship to assess LV work capability in each contractility. This relationship also shifted upward in enhanced contractility and downward in depressed contractility; the PVA at midrange V increased from 7.9 +/- 1.2 to 12.3 +/- 1.5 mmHg.ml.beat(-1).g(-1) and decreased from 8.2 +/- 0.9 to 6.4 +/- 0.8 mmHg.ml.beat(-1).g(-1). We conclude that the heights of the ESPVR and PVA-V relationship curves can evaluate LV contractility mechanoenergetically.
引用
收藏
页码:H2671 / H2678
页数:8
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