Clinical Isolates of Mycobacterium tuberculosis in Four European Hospitals Are Uniformly Susceptible to Benzothiazinones

被引：83

作者：

Pasca, Maria Rosalia ^{[1
]}

Degiacomi, Giulia ^{[1
]}

Ribeiro, Ana Luisa de Jesus Lopes ^{[1
,2
]}

Zara, Francesca ^{[3
]}

De Mori, Patrizia ^{[4
]}

Heym, Beate ^{[5
]}

Mirrione, Maurizio ^{[4
]}

Brerra, Roberto ^{[3
]}

Pagani, Laura ^{[3
]}

Pucillo, Leopoldo ^{[4
]}

Troupioti, Panajota ^{[6
]}

Makarov, Vadim ^{[7
]}

Cole, Stewart T. ^{[8
]}

Riccardi, Giovanna ^{[1
]}

机构：

[1] Univ Pavia, Dept Genet & Microbiol, I-27100 Pavia, Italy

[2] Univ Piemonte Orientale, DiSCAFF, I-28100 Novara, Italy

[3] Univ Pavia, Sez Microbiol, Dipartimento Sci Morfol Eidol & Clin, I-27100 Pavia, Italy

[4] INMI L Spallanzani IRCCS, Lab Anal Chim Clin & Microbiol, I-00149 Rome, Italy

[5] France Ouest Univ Versailles St Quentin en Yvelin, Hop Ambroise Pare, Fac Med Paris Ile, Serv Microbiol Hyg, F-92100 Boulogne, France

[6] Azienda Osped Valtellina & ValChiavenna, Lab Anal Chim Clin & Microbiol, Sondrio, Italy

[7] RAS, AN Bakh Biochem Inst, Moscow 119071, Russia

[8] Ecole Polytech Fed Lausanne, Global Hlth Inst, CH-1015 Lausanne, Switzerland

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 04期

关键词：

RESISTANCE;

D O I：

10.1128/AAC.01676-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The new antitubercular drug candidate 2-[2-S-methyl-1,4-dioxa-8-azaspiro[4.5]dec-8-yl]-8-nitro-6-(trifluoromethyl)4H- 1,3-benzothiazin-4-one (BTZ043) targets the DprE1 (Rv3790) subunit of the enzyme decaprenylphosphoryl-beta- D-ribose 2'-epimerase. To monitor the potential development of benzothiazinone (BTZ) resistance, a total of 240 sensitive and multidrug-resistant Mycobacterium tuberculosis clinical isolates from four European hospitals were surveyed for the presence of mutations in the dprE1 gene and for BTZ susceptibility. All 240 strains were susceptible, thus establishing the baseline prior to the introduction of BTZ043 in clinical trials.

引用

页码：1616 / 1618

页数：3

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