Effect of aggressive versus moderate lipid-lowering therapy on myocardial ischemia: The rationale, design, and baseline characteristics of the Study Assessing Goals in the Elderly (SAGE)

被引:10
作者
Deedwania, PC [1 ]
机构
[1] Univ Calif San Francisco, Sch Med, San Francisco, CA USA
关键词
D O I
10.1016/j.ahj.2004.06.026
中图分类号
R5 [内科学];
学科分类号
1002 [临床医学]; 100201 [内科学];
摘要
Background Patients with stable CHID who experience episodes of ischemia during routine daily activities are at increased, risk of coronary events. Older patients are at a particularly high risk. Few trials have specifically investigated the effects of lipid-lowering therapy with stains in older patients. Methods The SAGE trial is a prospective, randomized, double-blind, parallel-arm study enrolling men and women with stable CHD at 192 centers worldwide. Qualifying participants (aged 65-85 years; low-density lipoprotein cholesterol 100-250 mg/dL) have had at least 1 episode of myocardial ischemia with total ischemia duration greater than or equal to3 minutes on 48-hour ambulatory electrocardiographic (AECG) monitoring performed during routine daily activities. Participants have been randomized to either atorvastatin 80 mg/day (aggressive lipid lowering) or provastatin 40 mg/day (moderate lipid lowering). The primary efficacy measure is the absolute change in the total duration of myocardial ischemic events or. 48-hour AECG monitoring from baseline to month 12. Results SAGE is fully enrolled and 893 patients have been randomized. The majority of the study participants are white (97%) men (69%). The mean age of the participants is 72 years. Most participants (94%) have a history of angina. Other high-risk patient groups included in the study are patients with hypertension (65%), patients with diabetes (23%), and patients with peripheral vascular disease (12%). Conclusions SAGE will evaluate the effect of aggressive versus moderate lipid lowering on the total duration of myocardial ischemia in older ambulatory patients with CHD. It is likely to provide valuable data on the benefits of statins in this patient population.
引用
收藏
页码:1053 / 1059
页数:7
相关论文
共 37 条
[1]
Patients with mild heart failure worsen during withdrawal from digoxin therapy [J].
Adams, KF ;
Gheorghiade, M ;
Uretsky, BF ;
Young, JB ;
Ahmed, S ;
Tomasko, L ;
Packer, M .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1997, 30 (01) :42-48
[2]
*AM HEART ASS, 2003, HEART DIS STROK STAT
[3]
Andrews TC, 1997, CIRCULATION, V95, P324
[4]
USEFULNESS OF SILENT MYOCARDIAL ISCHEMIA DETECTED BY AMBULATORY ELECTROCARDIOGRAPHIC MONITORING IN PREDICTING NEW CORONARY EVENTS IN ELDERLY PATIENTS [J].
ARONOW, WS ;
EPSTEIN, S .
AMERICAN JOURNAL OF CARDIOLOGY, 1988, 62 (17) :1295-1296
[5]
Intensive versus moderate lipid lowering with statins after acute coronary syndromes [J].
Cannon, CP ;
Braunwald, E ;
McCabe, CH ;
Rader, DJ ;
Rouleau, JL ;
Belder, R ;
Joyal, SV ;
Hill, KA ;
Pfeffer, MA ;
Skene, AM .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (15) :1495-1504
[6]
Collins R, 2002, LANCET, V360, P7, DOI 10.1016/S0140-6736(02)09327-3
[7]
Effect of Atorvastatin (80 mg) on recurrent ischemia in unstable angina pectoris or non-ST-elevation acute myocardial infarction [J].
Correia, LCL ;
Magalhaes, LP ;
Santana, O ;
Rocha, MS ;
Passos, LCS ;
D'Oliveira, A ;
Esteves, JP ;
Spósito, AC .
AMERICAN JOURNAL OF CARDIOLOGY, 2003, 91 (11) :1355-1357
[8]
Low-density lipoprotein-independent effects of statins [J].
Davignon, J ;
Laaksonen, R .
CURRENT OPINION IN LIPIDOLOGY, 1999, 10 (06) :543-559
[9]
TRANSIENT ST-SEGMENT DEPRESSION AS A MARKER OF MYOCARDIAL ISCHEMIA DURING DAILY LIFE [J].
DEANFIELD, JE ;
SHEA, M ;
RIBIERO, P ;
DELANDSHEERE, CM ;
WILSON, RA ;
HORLOCK, P ;
SELWYN, AP .
AMERICAN JOURNAL OF CARDIOLOGY, 1984, 54 (10) :1195-1200
[10]
PREVALENCE AND PATTERNS OF SILENT-MYOCARDIAL-ISCHEMIA DURING DAILY LIFE IN STABLE ANGINA PATIENTS RECEIVING CONVENTIONAL ANTIANGINAL DRUG-THERAPY [J].
DEEDWANIA, PC ;
CARBAJAL, EV .
AMERICAN JOURNAL OF CARDIOLOGY, 1990, 65 (16) :1090-1096