Disturbed intracoronary hemodynamics in myocardial bridging - Early normalization by intracoronary stent placement

被引：185

作者：

Klues, HG ^{[1
]}

Schwarz, ER ^{[1
]}

vomDahl, J ^{[1
]}

Reffelmann, T ^{[1
]}

Reul, H ^{[1
]}

Potthast, K ^{[1
]}

Schmitz, C ^{[1
]}

Minartz, J ^{[1
]}

Krebs, W ^{[1
]}

Hanrath, P ^{[1
]}

机构：

[1] HELMHOLTZ INST BIOMED ENGN, AACHEN, GERMANY

来源：

CIRCULATION | 1997年 / 96卷 / 09期

关键词：

bridging; angiography; ultrasonics; pressure; stents;

D O I：

10.1161/01.CIR.96.9.2905

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background The purpose of this study was to evaluate the hemodynamic mechanisms leading to myocardial ischemia in patients with myocardial bridging. Myocardial bridging is known to induce angina and even severe myocardial ischemia. Methods and Results In 12 symptomatic patients with myocardial bridges, quantitative coronary angiography was performed to obtain systolic/diastolic vessel diameters within the bridged segments. Coronary flow velocities, flow reserve, and pressures were determined with a 0.014-in Doppler and a 0.014-in pressure microtransducer. In 3 symptomatic patients, coronary stents were implanted and hemodynamic measurements were repeated immediately and after 7 weeks. An in vitro validation of the pressure measurements was performed. Angiography revealed a systolic diameter reduction of 80.6+/-9.2% and a persistent diastolic reduction of 35.3+/-11% within the bridged segment. Diastolic flow velocities (cm/s) were increased (31.5+/-14.3 within versus 17.3+/-5.7 proximal and 15.2+/-6.3 distal, P<.001). Coronary flow reserve distal to the bridge was 2.5+/-0.5. There was an increased peak systolic pressure within the bridged segment (171+/-48 versus 113+/-10 mmHg proximal, P<.001). Stent placement abolished the phasic lumen compression, the diastolic flow abnormalities, the intracoronary peak systolic pressure, and clinical symptoms. Coronary flow reserve improved to 3.8+/-0.3. Conclusions Coronary hemodynamics in myocardial bridges are characterized by a phasic systolic vessel compression with a localized peak pressure, persistent diastolic diameter reduction, increased blood flow velocities, retrograde flow, and a reduced flow reserve. These alterations may explain the occurrence of symptoms and ischemia in these patients. Intracoronary stent placement abolished all hemodynamic abnormalities and may improve clinical symptoms in otherwise unsuccessfully treated patients with myocardial bridges.

引用

页码：2905 / 2913

页数：9

共 43 条

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