Anti-androgen Treatments

1. Estrogen plus progestin contraceptives (EPP) are the first-line treatment of moderate hirsutism and acne in women of child bearing age (grade C). 2. CPA, 50 mg/day, 20 days out of 28, associated With estrogen is the first-line treatment of "moderate to severe hirsutism" in women of childbearing age (grade C). 3. Spironolactone. given as a contraceptive, Call be proposed as a second-line treatment in case of side effects or counter-indications to CPA ill moderate to severe hirsutism (grade C) in women of childbearing age. No market authorization in this indication. 4. Flutamide or Finasteride are "only" to be used under the guise of contraception as a "thirdline therapy" in cases of severe hirsutism, the presence of side effects or counter-indications to EPP CPA 50 mg/day or spironolactone (grade C). No Market authorization in this indication 5. There is no indication for GnRH analogs as an anti-androgen treatment in women of childbearing age given the current therapeutic alternatives (grade C) 6. Only long-term hair removal treatments can he proposed (grade C): electrolysis or laser hair removal. (C) 2010 Published by Elsevier Masson SAS.