Therapeutic opportunities from tumour biology in metastatic colon cancer

被引：40

作者：

McLeod, HL ^{[1
]}

McKay, JA ^{[1
]}

Collie-Duguid, ESR ^{[1
]}

Cassidy, J ^{[1
]}

机构：

[1] Univ Aberdeen, Inst Med Sci, Dept Med & Therapeut, Aberdeen AB25 2ZD, Scotland

来源：

EUROPEAN JOURNAL OF CANCER | 2000年 / 36卷 / 13期

关键词：

colorectal cancer; metastasis; developmental therapeutics; gene therapy;

D O I：

10.1016/S0959-8049(00)00150-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumour metastasis is the major cause of morbidity and mortality from colorectal cancer. While improvements in duality of life and patient survival have been made over the past 10 years, the majority of patients with metastatic colorectal cancel will die from their disease. As knowledge of the biology of colon cancer and its invasion/metastasis programme evolve, this presents new therapeutic opportunities for pharmacological and genetic intervention. This review discusses the current approaches to metastatic colorectal cancer therapy, details genomic and biological variance between primary and metastatic tumours, and highlights approaches for harnessing these differences to improve therapy. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1706 / 1712

页数：7

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