Epidemiology, risk factors, and outcomes of Candida albicans versus non-albicans candidemia in nonneutropenic patients

被引:52
作者
Davis, Susan L.
Vazquez, Jose A.
McKinnon, Peggy S.
机构
[1] Barnes Jewish Hosp, St Louis, MO 63110 USA
[2] Wayne State Univ, Detroit, MI 48202 USA
[3] Henry Ford Hosp, Infect Dis Consulting Staff, Detroit, MI 48202 USA
关键词
Candida albicans; non-albicans;
D O I
10.1345/aph.1H516
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Background: Candidemia is a major cause of morbidity and mortality in hospitalized patients. Objectives: To describe the epidemiology of and risk factors for non-albicans candidemia (NAC) in nonneutropenic adults and the impact of NAC on patient outcomes and treatment cost. Methods: We conducted a retrospective cohort analysis comparing demographics and risk factors for Candida albicans candidema (CAC) versus NAC in 144 non-neutropenic patients with candidemia over a 6 year period (1997-2002) at Detroit Receiving Hospital. Results: Candida species distribution included albicans (50%), parapsilosis (13%), tropicalis (10%), and glabrata (13%). Predominant species varied by patient care unit, with c. parapsilosis in the burn ICU. In multivariate analysis, NAC was associated with the absence of antibiotic use at the onset of candidemia, recent history of solid tumor, and male sex. NAC was not associated with an increase in mortality or length of stay compared with CAC, but was found to have a higher cost of antifungal therapy ($2030 vs $780; p = 0.05). Conclusions: The epidemiology of candidemia is complex and varies among the different patient care units. Specifically, patients appear less likely to develop NAC if they are receiving antibiotics at the onset of candidemia. Increased awarness of the risk factors for NAC can be used to guide adequate inital antifungal therapy.
引用
收藏
页码:568 / 573
页数:6
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