Metal-enhanced fluorescence: Potential applications in HTS

被引：52

作者：

Geddes, CD

Gryczynski, I

Malicka, J

Gryczynski, Z

Lakowicz, JR

机构：

[1] Univ Maryland, Ctr Fluorescence Spect, Inst Biotechnol, Ctr Med Biotechnol, Baltimore, MD 21201 USA

[2] Univ Maryland, Inst Fluorescence, Inst Biotechnol, Ctr Med Biotechnol, Baltimore, MD 21201 USA

来源：

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING | 2003年 / 6卷 / 02期

关键词：

D O I：

10.2174/1386207033329760

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Metallic surfaces and particles can have dramatic effects on fluorescence, including localized excitation, increased quantum yields, increased photostability and increased distances for resonance energy transfer (RET), and directional emission. While all these effects have not yet been realized in a single system, metal-enhanced fluorescence promises to provide the next generation of high sensitivity fluorescence assays for low copy number detection of biochemical species.

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收藏

页码：109 / 117

页数：9

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