Characterization and activity of sonochemically-prepared BSA microspheres containing Taxol - An anticancer drug

被引：49

作者：

Grinberg, Olga

Hayun, Michal

Sredni, Benjamin

Gedanken, Aharon ^{[1
]}

机构：

[1] Bar Ilan Univ, Dept Chem, Ctr Adv Mat & Nanotechnol, IL-52900 Ramat Gan, Israel

[2] Bar Ilan Univ, Kanbar Lab Nanomat, Ctr Adv Mat & Nanotechnol, IL-52900 Ramat Gan, Israel

[3] Bar Ilan Univ, Mina & Everard Goodman Fac Life Sci, IL-52900 Ramat Gan, Israel

来源：

ULTRASONICS SONOCHEMISTRY | 2007年 / 14卷 / 05期

关键词：

sonochemistry; bovine serum albumin; anticancer drug carrier; proteinaceous microspheres; taxol;

D O I：

10.1016/j.ultsonch.2006.11.004

中图分类号：

O42 [声学];

学科分类号：

070206 [声学]; 082403 [水声工程];

摘要：

Proteinaceous microspheres of BSA (Bovine Serum Albumin) containing an anticancer drug, Taxol (paclitaxel) were fabricated using a sonochemical procedure and then assayed for chemical and biological activity. The sonochemical reaction did not compromise the drug, which became encapsulated in the BSA microspheres. The amount of the anticancer drug in the microspheres was determined by HPLC. Anticancer activity of the proteinaceous microspheres encapsulating the Taxol was tested on Mouse Multiple Myeloma cell line MPG-11. The influence of the Taxol microspheres on the cancer cells was different from pristine Taxol. It was found that Taxol in combination with the organic solvent causes the death of cancer cells. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：661 / 666

页数：6

共 34 条

[1]

An easy sonochemical route for the encapsulation of tetracycline in bovine serum albumin microspheres [J].