Novel interactions between K+ channels and scorpion toxins

被引：142

作者：

de la Vega, RCR ^{[1
]}

Merino, E ^{[1
]}

Becerril, B ^{[1
]}

Possani, LD ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Inst Biotechnol, Cuernavaca 62210, Morelos, Mexico

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2003年 / 24卷 / 05期

关键词：

D O I：

10.1016/S0165-6147(02)00080-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

K+ channels are macromolecules embedded in biological membranes, where they play a key role in cellular excitability and signal transduction pathways. Knowledge of their structure should help improve our understanding of their function and lead to the design of therapeutic compounds. Most pharmacological and structural characteristics of these channels have been elucidated by using high-affinity channel blockers isolated from scorpion venoms. Recent data on the three-dimensional structures of K+ channels and novel scorpion toxins suggest a variety of novel interacting modes of these channels and toxins, which should help increase our understanding of the K+ channel structure-function relationship.

引用

页码：222 / 227

页数：6

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