Single neurons in the monkey hippocampus and learning of new associations

被引:260
作者
Wirth, S
Yanike, M
Frank, LM
Smith, AC
Brown, EN
Suzuki, WA [1 ]
机构
[1] NYU, Ctr Neural Sci, New York, NY 10003 USA
[2] Harvard Univ, Massachusetts Gen Hosp, Sch Med,Dept Anesthesia & Crit Care, Harvard MIT Div Hlth Sci & Technol, Boston, MA 02114 USA
关键词
D O I
10.1126/science.1084324
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The medial temporal lobe is crucial for the ability to learn and retain new declarative memories. This form of memory includes the ability to quickly establish novel associations between unrelated items. To better understand the patterns of neural activity during associative memory formation, we recorded the activity of hippocampal neurons of macaque monkeys as they learned new associations. Hippocampal neurons signaled learning by changing their stimulus-selective response properties. This change in the pattern of selective neural activity occurred before, at the same time as, or after learning, which suggests that these neurons are involved in the initial formation of new associative memories.
引用
收藏
页码:1578 / 1581
页数:4
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