LKB1 - A master tumour suppressor of the small intestine and beyond

被引：94

作者：

Yoo, LI ^{[1
]}

Chung, DC ^{[1
]}

Yuan, JY ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Gastrointestinal Unit, Boston, MA 02114 USA

来源：

NATURE REVIEWS CANCER | 2002年 / 2卷 / 07期

关键词：

D O I：

10.1038/nrc843

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Peutz-Jeghers syndrome (PJS) is a rare, inherited intestinal polyposis syndrome that is associated with a significantly increased risk of several types of cancer - particularly those of the gastrointestinal and reproductive systems. Most cases of PJS have been associated with loss-of-function mutations in the ubiquitously expressed LKB1 gene, which encodes a serine/threonine kinase. Recent studies have begun to illustrate the molecular mechanisms by which LKB1 functions as an important new tumour suppressor.

引用

页码：529 / 535

页数：7

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