Hydrolysis of oxaliplatin - Evaluation of the acid dissociation constant for the oxalato monodentate complex

Alkaline hydrolysis of the platinum anticancer drug oxaliplatin gives the oxalato monodentate complex and the dihydrated oxaliplatin complex in two consecutive steps. The acid dissociation constant for the oxalato monodentate intermediate was determined by a kinetic approach. The pK(a) value was estimated as 7.23. The monodentate intermediate is assumed to rapidly react with endogenous compounds, resulting in a continuous conversion of oxaliplatin via the monodentate form. (C) 2003 Wiley-Liss, Inc. and the American Pharmaceutical Association.