Synthesis of α-aryl N-adamant-1-yl nitrones and using them for spin trapping of hydroxyl radicals

被引：15

作者：

Sár, CP

Hideg, É

Vass, I

Hideg, K

机构：

[1] Univ Pecs, Inst Organ & Med Chem, H-7643 Pecs, Hungary

[2] Biol Res Ctr, Inst Plant Biol, H-6701 Szeged, Hungary

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(98)00033-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

alpha-Aryl N-adamant-1-yl nitrones were synthesized and evaluated with respect to the stability of the hydroxyl radical adduct. The polarity and water solubility of nitrones were altered with changing the alpha-aryl groups. Introduction of adamantane ring instead of tert-butyl group resulted in a reasonable good stability of hydroxyl radical adduct for biological measurements. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：379 / 384

页数：6

共 19 条

[1] QUANTITATIVE ASPECTS OF ELECTRON-SPIN-RESONANCE AND SPIN TRAPPING OF HYDROXYL RADICALS AND HYDROGEN-ATOMS IN GAMMA-IRRADIATED AQUEOUS-SOLUTIONS [J].